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KMID : 0352720210450030450
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Journal of Ginseng Research
2021 Volume.45 No. 3 p.450 ~ p.455
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Effect of Korean Red Ginseng through comparative analysis of cardiac gene expression in db/db mice
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Jang Young-Jin
Aravinthan Adithan
Hossain Mohammad Amjad
Kopalli Spandana Rajendra
Kim Bum-Seok
Kim Nam-Soo
Kang Chang-Won
Kim Jong-Hoon
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Abstract
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Korean Red Ginseng (KRG) is an herbal oriental medicine known to alleviate cardiovascular dysfunction. To analysis the expression of diabetic cardiac complication-associated genes in db/db mice, we studied the cardiac gene expression following KRG treatment. In result, a total of 585 genes were found to be changed in db/db mice. Among the changed expression, 245 genes were found to 2-fold upregulated, and 340 genes were 2-fold downregulated. In addition, the changed gene expressions were ameliorated by KRG. In conclusion, KRG may be possible to normalize cardiac gene expressions in db/db mice.
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KEYWORD
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Panax ginseng, Diabetes mellitus, Diabetic cardiac complication, Microarray, Gene profiling
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